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Advances in Obesity, Endocrinology, and Diabetes

Published

Effectiveness of Laser Therapy in the Treatment of Diabetic Foot Ulcers: A Systematic Review

Published in July - December 2026 (Vol. 3, Issue 2, 2026)

Effectiveness of Laser Therapy in the Treatment of Diabetic Foot Ulcers:  A  Systematic Review - Issue cover

Abstract

Background: Diabetic foot ulcers (DFUs) are among the most serious and costly complications of diabetes mellitus, often leading to infection, amputation, and a significant decline in quality of life. Despite conventional treatment strategies, many DFUs remain slow to heal or unresponsive, prompting interest in complementary therapies. Low-Level Laser Therapy (LLLT) has emerged as a non- invasive, painless, and potentially effective modality to enhance ulcer healing through mechanisms like improved microcirculation and tissue regeneration. Objective: This systematic review aims to evaluate the effectiveness of Low-Level Laser Therapy (LLLT) in promoting the healing of diabetic foot ulcers in patients with type 2 diabetes. Methods: A systematic literature search was conducted using PubMed and Elsevier databases up to April 2025. Studies were included if they investigated the use of LLLT in treating DFUs in type 2 diabetic patients. Inclusion criteria focused on randomized controlled trials and clinical studies available in English or French. Study selection followed the PRISMA 2020 guidelines, and a narrative synthesis of outcomes was performed. Risk of bias was assessed using the Cochrane Collaboration’s tool. Results: Eight studies met the inclusion criteria, including randomized controlled trials, systematic reviews, and clinical studies, with sample sizes ranging from 7 to 413 participants. The findings consistently demonstrated that LLLT significantly reduced ulcer size, accelerated healing time, improved pain management, and enhanced granulation without reported adverse effects. While heterogeneity existed in laser parameters and treatment protocols, the overall quality of evidence was considered high. Conclusion: LLLT appears to be a safe, effective, and well-tolerated adjunctive treatment for diabetic foot ulcers. Its ability to promote wound healing and reduce complications offers promising implications for clinical practice. However, further large-scale and standardized trials are needed to confirm these findings and establish optimal treatment guidelines.

References

  1. [1]Santos CMD, Rocha RB da, Hazime FA, Cardoso VS. A Systematic Review and Meta-Analysis of the Effects of Low-Level Laser Therapy in the Treatment of Diabetic Foot Ulcers. Int J Low Extrem Wounds. sept 2021;20(3):198-207.
  2. [2]athur RK, Sahu K, Saraf S, Patheja P, Khan F, Gupta PK. Low-level laser therapy as an adjunct to conventional therapy in the treatment of diabetic foot ulcers. Lasers Med Sci. févr 2017;32(2):275-82.
  3. [3]Huang J, Chen J, Xiong S, Huang J, Liu Z. The effect of low-level laser therapy on diabetic foot ulcers: A meta-analysis of randomised controlled trials. Int Wound J. déc 2021;18(6):763-76.
  4. [4]Feitosa MCP, Carvalho AFM de, Feitosa VC, Coelho IM, Oliveira RA de, Arisawa EÂL. Effects of the Low-Level Laser Therapy (LLLT) in the process of healing diabetic foot ulcers. Acta Cir Bras. déc 2015;30(12):852-7.
  5. [5]Li S, Wang C, Wang B, Liu L, Tang L, Liu D, et al. Efficacy of low-level light therapy for treatment of diabetic foot ulcer: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. sept 2018;143:215-24.
  6. [6]Tchanque-Fossuo CN, Ho D, Dahle SE, Koo E, Li CS, Isseroff RR, et al. A systematic review of low-level light therapy for treatment of diabetic foot ulcer. Wound Repair Regen. mars 2016;24(2):418-26.
  7. [7]Kazemi-Khoo N. Successful treatment of diabetic foot ulcers with low-level laser therapy. The Foot. déc 2006;16(4):184-7.
  8. [8]M. J. LP, E. P. KB, A. IT. Effect of low level laser therapy on diabetic foot ulcers: a randomized control trial. Int Surg J. 26 févr 2018;5(3):1008.
  9. [9]Zhou Y, Chia HWA, Tang HWK, Lim SYJ, Toh WY, Lim XL, et al. Efficacy of low-level light therapy for improving healing of diabetic foot ulcers: A systematic review and meta-analysis of randomized controlled trials. Wound Repair Regen. janv 2021;29(1):34-44.
  10. [10]Beckmann KH, Meyer-Hamme G, Schröder S. Low level laser therapy for the treatment of diabetic foot ulcers: a critical survey. Evid Based Complement Alternat Med. 2014;2014:626127.
  11. [11]Waluyo Y, Hidayat MS. Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing. Am J Case Rep. 3 juill 2024;25:e944106.
  12. [12]Brem H, Sheehan P, Rosenberg HJ, Schneider JS, Boulton AJM. Evidence-Based Protocol for Diabetic Foot Ulcers: Plastic and Reconstructive Surgery. juin 2006;117(SUPPLEMENT):193S-209S.
  13. [13]Waluyo Y, Hidayat MS. Low-Level Laser Therapy (LLLT) for Diabetic Foot Ulcer in Uncontrolled Diabetes: A Case Report of Improved Wound Healing. Am J Case Rep. 3 juill 2024;25:e944106.
  14. [14]Kajagar BM, Godhi AS, Pandit A, Khatri S. Efficacy of Low Level Laser Therapy on Wound Healing in Patients with Chronic Diabetic Foot Ulcers—A Randomised Control Trial. Indian J Surg. oct 2012;74(5):359-63.

Authors (11)

Mouna Elleuch

Hedi Chaker Hospital, Sfax uni...

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Khouloud Boujelbene

Hedi Chaker Hospital, Sfax uni...

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Zeinab Krichen

Hedi Chaker Hospital, Sfax uni...

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Mariem Maaoui

Hedi Chaker Hospital, Sfax uni...

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Roua Ellouze

Hedi Chaker Hospital, Sfax uni...

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Zaineb Fourati

Hedi Chaker Hospital, Sfax uni...

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Nadia Charfi

Hedi Chaker Hospital, Sfax uni...

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Faten Hadj Kacem

Hedi Chaker Hospital, Sfax uni...

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Mouna Mnif

Hedi Chaker Hospital, Sfax uni...

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Dhouha Ben Salah

Hedi Chaker Hospital, Sfax uni...

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Nabila Rekik

Hedi Chaker Hospital, Sfax uni...

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AOEDS230052

AOEDS-01-000051

2026-05-27

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How to Cite

Elleuch & Boujelbene & Krichen & Maaoui & Ellouze & Fourati & Charfi & Hadj, F. & Mnif & Ben, D. & Rekik (2026). Effectiveness of Laser Therapy in the Treatment of Diabetic Foot Ulcers: A Systematic Review. Advances in Obesity, Endocrinology, and Diabetes, 3(2), xx-xx. https://aoeds.com/articles/AOEDS230052

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