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Advances in Obesity, Endocrinology, and Diabetes

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Successful desensitization by Detemir administration in a patient with insulin allergy: A case report

Ben Nacef Ibtissem
,
Kastalli Sarra
,
Mekni Sabrine
,
Essayeh Saousen
,
Lamouri Rihab
,
Mchirgui Nadia
,
Lakhoua Youssef
,
Khiari Karima
,
Rojbi imen

Published in January-June 2025 (Vol. 2, Issue 1, 2025)

Successful desensitization by Detemir administration in a patient with insulin allergy: A case report - Issue cover

Keywords

insulinallergydesensitizationinsulin analogues

Abstract

Introduction: Insulin allergy is a rare clinical condition. The frequency of insulin allergy has decreased since highly purified insulin préparations became available. However, it remains a concern, and its frequency may have increased with the latest generation of insulin analogues. Case Presentation: We report the case of a 51-year-old female patient with type 2 diabetes who required multiple daily insulin injections. The patient developed an allergy to human regular insulin and insulin analogues (insulin aspart and insulin glargine), which was resolved through subcutaneous insulin desensitization. Conclusion: As reported in this case, desensitization with subcutaneously administered human insulin using an ultra-rush protocol in patients with insulin allergy may offer a simple and successful therapy within a few days.

Authors (9)

Ben Nacef Ibtissem

Department of endocrinology, C...

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Kastalli Sarra

Pharmacovigilance Department, ...

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Mekni Sabrine

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Essayeh Saousen

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Lamouri Rihab

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Mchirgui Nadia

Department of endocrinology, C...

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Lakhoua Youssef

Department of endocrinology, C...

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Khiari Karima

Department of endocrinology, C...

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Rojbi imen

Department of endocrinology, C...

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Published in:

January-June 2025 (Vol. 2, Issue 1, 2025)

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How to Cite

Ben Nacef Ibtissem & , K. & , M. & , E. & , L. & , M. & , L. & , K. & imen (2025). Successful desensitization by Detemir administration in a patient with insulin allergy: A case report. Advances in Obesity, Endocrinology, and Diabetes, 2(1), xx-xx. https://aoeds.com/articles/aoeds-00000016

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