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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2026

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2026

Volume 3, Issue 1 - 2026 (Jan-June 2026)

Volume 3 Issue 1 Cover

Issue Details:

Volume 3 Issue 1
Published:Jan 20, 2026

Editorial: Jan-June 2026

Welcome to the 2026 issue of Advances in Obesity, Endocrinology, and Diabetes. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Lakshmi Nagendra
Editor-in-Chief
Advances in Obesity, Endocrinology, and Diabetes

Articles in This Issue

Showing 7 of 7 articles
Research PaperID: aoeds-00000038

Editorial: Diabetes Insipidus to be retired happily in history books

IHAB ElTAYEB

In 1794, Johann Peter Frank coined the term “diabetes insipidus” to distinguish patients with this condition from those who had diabetes mellitus. A collaborative team of professionals from various international endocrinology and pediatric organizations is now recommending a change in nomenclature. They suggest that "diabetes insipidus" be replaced with “arginine vasopressin deficiency (AVP-D)” for cases of central origin, while proposing the term “arginine vasopressin resistance (AVP-R)” for nephrogenic cases (1)

Diabetes InsipidusArginine vasopressin deficiencyArginine vasopressin resistanceFond farewell
93 views
32 downloads

Contributors:

 IHAB ElTAYEB
Research PaperID: aoeds-00000041

Management of ACTH-Dependent Cushing’s disease with Resistant Hypertension and “Kissing Carotids”: A Challenging Pituitary Case

Ben Nacef ibtissem, Baltagi Myriam, Sabrine Mekni, Rihab Laamouri, Karima Khiari, Rojbi Imen

Background: Cushing’s disease (CD), caused by an ACTH-secreting pituitary adenoma, remains one of the most challenging endocrine disorders to diagnose and treat. The coexistence of resistant hypertension, metabolic complications, and complex vascular anatomy such as “kissing carotids” further complicates management. Case Presentation: We report a 40-year-old man with long-standing hypertension referred for evaluation of resistant blood pressure. Physical examination revealed classical Cushingoid features. Endocrine testing confirmed ACTH-dependent Cushing’s syndrome. Pituitary MRI was limited by a rare vascular variant medialized internal carotid arteries (“kissing carotids”) which obscured visualization of the adenoma. The patient underwent endoscopic transsphenoidal surgery in a specialized neurosurgical center, confirming a corticotroph adenoma. Postoperatively, cortisol levels normalized, and metabolic and cardiovascular comorbidities markedly improved. Conclusion: This case highlights the diagnostic and therapeutic complexity of ACTH-dependent Cushing’s disease with challenging pituitary anatomy. Expert multidisciplinary management remains essential to achieve remission and prevent long-term sequelae.

Cushing’s diseaseACTH-dependent hypercortisolism,resistant hypertensionpituitary adenomatranssphenoidal surgerykissing carotid arteries+4 more
73 views
14 downloads

Contributors:

 Ben Nacef ibtissem
,
 Baltagi Myriam
,
 Sabrine Mekni
,
 Rihab Laamouri
,
 Karima Khiari
,
 Rojbi Imen
Research PaperID: aoeds-00000042

Comparative Efficacy of Bariatric Surgeries for Type 2 Diabetes Mellitus Remission: A Systematic Review and Network Meta-Analysis

Haitham A. A. Sawalmeh, Ihab El-Tayeb, Faisal Badri, Alya Al-Mazrouei

Background: Bariatric surgery plays a pivotal role in the management of obesity and metabolic disorders, including type 2 diabetes mellitus (T2DM). However, the relative efficacy of different surgical procedures in achieving durable T2DM remission remains unclear. Methods: A systematic review and network meta-analysis (NMA) were conducted according to PRISMA-NMA guidelines. Searches were performed across PubMed, Embase, Scopus, and Cochrane Library (2000–2024). Eligible studies included randomized controlled trials and prospective cohorts comparing sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one-anastomosis gastric bypass (OAGB). The primary endpoint was complete T2DM remission (HbA1c

Bariatric surgeryT2DM remissionSleeve gastrectomyRoux-en-Y gastric bypassOne-anastomosis gastric bypassNetwork meta-analysis
66 views
11 downloads

Contributors:

 Haitham A. A. Sawalmeh
,
 Ihab El-Tayeb
,
 Faisal Badri
,
 Alya Al-Mazrouei
Research PaperID: aoeds-00000043

Case study: Successful medical treatment of congenital hyperinsulinism with pasireotide in a 12- year-old child

Ibtissem Ben Nacef, Fatma Kammoun, Sabrine Mekni, Sawsen Essayeh, Rihab Laamouri, Nadia Mchirgui, Karima Khiari, Imen Rojbi

Background: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in neonates and children. Prompt diagnosis and treatment is important to avoid long-term neurological damage. In diazoxide-unresponsive cases, somatostatin receptor analogs are used in second line. Pasireotide, which has a higher affinity for the somatostatin receptor 5 than first-generation somatostatin analogs, was trialed in a pediatric patient with hyperinsulinism. Case description: The patient presented at the age of 8 years with recurrent episodes of nonfasting hypoglycemia and neuroglycopenic symptoms. A diagnosis of autonomous insulin secretion was biochemically confirmed by elevated levels of insulin (22.9 µUI/mL > 3 µUI/mL) and C-peptide (3.43 ng/mL > 0.6 ng/mL) during hypoglycemia (glucose 2.03 mmol/L). Glucose infusion rate to maintain euglycemia was 7 (mg/kg/min). The patient was initially treated by frequent feeding with carbohydrate-enriched formula and diazoxide 10 mg/kg/day. At the age of 12 years treatment with subcutaneous injections of octreotide was added because of recurrent hypoglycemia. Six months later and with parental consent, long acting pasireotide 40 mg every 28 days was initiated. Common side effects associated with pasireotide were carefully monitored, but did not occur. The patient was normoglycemic with a good growth rate, normal weight gain, and excellent neurodevelopment. Conclusion: This case study adds to findings reported previously suggesting that pasireotide may be a valuable option in second-line treatment of hyperinsulinism.

congenital hyperinsulinismpasireotidecase report
44 views
12 downloads

Contributors:

 Ibtissem Ben Nacef
,
 Fatma Kammoun
,
 Sabrine Mekni
,
 Sawsen Essayeh
,
 Rihab Laamouri
,
 Nadia Mchirgui
,
 Karima Khiari
,
 Imen Rojbi
Research PaperID: aoeds-00000044

Recurrent Hypoglycaemia in a 7-Year-Old with Genetically Complex, Diazoxide-Responsive Congenital Hyperinsulinism

Mustafa AlQaysi, MD, Bashar Sahar, MRes, Ebtehaj Al Anizi, MD, Mohanad Atta, MD, Rawnaq Adnan Abbas, MD,

Background: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in children, most frequently caused by pathogenic variants in ABCC8 or KCNJ11, encoding subunits of the pancreatic KATP channel (1,3). Case presentation: A previously healthy 7-year-old boy presented with recurrent early morning hypoglycaemia associated with lethargy, sweating and confusion. Biochemical evaluation confirmed hyperinsulinaemic hypoglycaemia with suppressed ketones and free fatty acids. He responded completely to diazoxide, indicating functional KATP channel involvement. Whole-exome sequencing identified no clearly pathogenic variants but several variants of uncertain significance (VUS) in ABCC8, KCNJ11, and HNF1A, including a homozygous deep intronic variant (ABCC8: c.2256-50T>C) potentially affecting splicing (2,3). Outcome: The patient achieved full remission with diazoxide therapy, frequent carbohydrate intake, and bedtime cornstarch supplementation. Conclusion: This case illustrates the diagnostic complexity of CHI with multiple VUS and highlights the clinical utility of diazoxide responsiveness as a functional marker of KATP channel dysfunction. Functional studies of deep intronic variants and polygenic interactions remain essential for accurate molecular diagnosis (2,3).

Congenital hyperinsulinismABCC8KCNJ11diazoxide-responsive hypoglycaemiawhole-exome sequencingvariants of uncertain significance
42 views
12 downloads

Contributors:

 Mustafa AlQaysi, MD
,
 Bashar Sahar, MRes
,
 Ebtehaj Al Anizi, MD
,
 Mohanad Atta, MD
,
 Rawnaq Adnan Abbas, MD,
Research PaperID: aoeds-00000045

Development of Disseminated Tuberculosis in a Non-Immunocompromised Patient Following COVID-19 Infection: A Case Report

Ensiyeh Rahimi, Sara Ghaderkhani

Background: The COVID-19 pandemic has been associated with various complications and has altered patterns of disease presentation. COVID-19 is known to affect the immune system. We report a case of disseminated tuberculosis (TB) in a previously non-immunocompromised patient with a history of COVID-19 infection. Case Presentation: A 25-year-old woman with a history of mild COVID-19 infection three months earlier developed progressive back pain followed by worsening headache. She was eventually admitted with decreased level of consciousness, delirium, and focal neurological deficits. Further evaluation confirmed disseminated tuberculosis, including miliary pulmonary TB, TB meningitis, and TB spondylodiscitis. The patient showed gradual clinical and neurological improvement following anti-tuberculosis therapy. Conclusions: This case suggests a possible association between COVID-19 infection and subsequent development of disseminated tuberculosis, even in immunocompetent individuals.

COVID-19tuberculosisdisseminated TB
44 views
13 downloads

Contributors:

 Ensiyeh Rahimi
,
 Sara Ghaderkhani
Research PaperID: aoeds-00000046

Case Report - A case of neglected chronic back pain resulting in delayed diagnosis of parathyroid adenoma.

Dr. Apsia Ruhi, Dr. Valarmathi Ramachandran, Dr. Faiza Jamil

Primary hyperparathyroidism is an important yet often overlooked cause of the chronic musculoskeletal pain. A delay in diagnosis may result in significant skeletal complications. We report a case of longstanding neglected back pain that ultimately led to the diagnosis of parathyroid adenoma. This case highlights the importance of considering metabolic causes in patients with persistent musculoskeletal symptoms and early evaluation to prevent irreversible complications.

Chronic back painparathyroid adenomaprimary hyperparathyroidismdelayed diagnosisosteoporosis
49 views
11 downloads

Contributors:

 Dr. Apsia Ruhi
,
 Dr. Valarmathi Ramachandran
,
 Dr. Faiza Jamil

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