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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Advances in Obesity, Endocrinology, and Diabetes</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AOEDS</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">3049-0715</issn>
      <publisher>
        <publisher-name>Dr Lakshmi Nagendra</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">aoeds-00000012</article-id>
      <title-group>
        <article-title>Challenges in the Management of Cushing’s Syndrome Associated with Double ACTH-Secreting Pituitary Adenomas: A Case Report</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Hasni</surname>
            <given-names>Yosra</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>FEKIH</surname>
            <given-names>Hamza EL</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>KHochtali</surname>
            <given-names>Riheb</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>BRAHEM</surname>
            <given-names>Salem BEN</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>SAAFI</surname>
            <given-names>Wiem</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>MAAROUFI</surname>
            <given-names>Amel</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Department of Endocrinology and Diabetology, Farhat Hached University Hospital of Sousse, Faculty of Medicine of Sousse, University of Sousse 4000 Sousse, Tunisia</aff>
      <aff id="aff2">Department of Radiology, Farhat Hached University Hospital of Sousse, Faculty of Medicine of Sousse, University of Sousse</aff>
      <pub-date pub-type="epub" iso-8601-date="2026">
        <year>2026</year>
      </pub-date>
      <volume>1</volume>
      <issue>1</issue>
      <abstract>
        <p>
Cushing&apos;s disease (CD) is a rare endocrine disorder primarily caused by a corticotroph pituitary microadenoma. The occurrence of double pituitary adenomas (DPA), particularly with two ACTH-secreting microadenomas, is exceptionally uncommon. Untreated or poorly managed CD can lead to severe complications, such as bilateral avascular necrosis of the femoral heads.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Cushing&apos;s disease</kwd>
        <kwd>DPA</kwd>
        <kwd>ACTH</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
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